Yes, dietary supplements can potentially interact with prescription medications. Some supplements contain active ingredients that can interfere with the metabolism, absorption, or efficacy of certain drugs. For example, St. John's Wort can interact with antidepressants, and vitamin K supplements can interfere with blood-thinning medications. It is important to consult with a healthcare professional, such as a doctor or pharmacist, before taking any dietary supplements, especially if you are currently on prescription medications, to ensure there are no potential interactions or adverse effects.