The long-term effects of taking pain medications can vary depending on the type of medication and the individual. Common side effects of long-term use of pain medications include constipation, nausea, drowsiness, and addiction. Additionally, long-term use of pain medications can lead to liver and kidney damage, as well as an increased risk of stroke and heart attack. It is important to talk to a doctor before taking any pain medications to ensure that the risks are understood and minimized.