Squeezing the toothpaste tube from the bottom and then rolling it is a popular method for getting the most out of the toothpaste. The advantage of this method is that it allows you to evenly distribute the toothpaste throughout the tube and helps ensure that you use every last drop of toothpaste. Additionally, it prevents the tube from being over-squeezed, which can lead to toothpaste spilling out of the tube.