Girls experiencing period cramps can consider taking over-the-counter pain relievers such as ibuprofen or acetaminophen to help alleviate the pain. These medications can help reduce inflammation and provide temporary relief from menstrual cramps. However, it's essential to consult with a healthcare professional or pharmacist to ensure the medication is safe and appropriate for individual circumstances. Additionally, there are non-medical approaches that may help, such as applying a heating pad to the lower abdomen, practicing relaxation techniques, or engaging in light physical exercise.