The line "You talkin to me?" is from the 1976 film Taxi Driver, starring Robert De Niro.
Taxi Driver is a 1976 American psychological thriller film directed by Martin Scorsese and written by Paul Schrader. The film stars Robert De Niro as a mentally unstable Vietnam War veteran who works as a taxi driver in New York City. The famous line "You talkin to me?" is delivered by De Niro's character, Travis Bickle. The film was a critical and commercial success, and was nominated for four Academy Awards, including Best Picture. It is widely regarded as one of the greatest films of all time.