As for me, there is no particular course that's best to take in college. It all depends on the subjects you are good at while you were still in high school. You wouldn't want a situation whereby you are going for a particular course because it's seen as best, yet knowing that you are not having a sound foundation to excel in it.
Let's take for example, you consider an engineering course to be the best, and unfortunately, you're not good in calculative subjects. Now, you see it won't serve your initial perception of considering engineering course as the best.
In summary, best course for me would be that course I am passionate about and also have indepth knowledge on, so that if I take it as my course of discipline, I would come out with flying colours that would enable me to secure a well paid job.