The most expensive spice in the world by weight is saffron. It is obtained from the saffron crocus flower and is known for its distinct aroma and intense flavor. Saffron is used in a variety of dishes and is popularly used in Indian, Persian, and Mediterranean cuisine. The high price of saffron is attributed to the labor-intensive harvesting process, as each thread is handpicked from the flower. It takes approximately 75,000 saffron flowers to produce just one pound of saffron, making it a rare and precious spice.