Muhammad Ali fought against many boxers throughout his career, but he had a few losses as well. One famous boxer who defeated Muhammad Ali was Joe Frazier, also known as Smokin' Joe. The two boxers had an intense rivalry, and they faced each other three times in the ring. In their first match, which was billed as the "Fight of the Century," Joe Frazier won by decision. Muhammad Ali would go on to defeat Frazier in their next two matches, but Frazier's victory was a significant moment in boxing history.