The first super villain that Spider-Man encountered was the infamous "Vulture". In the first issue of "The Amazing Spider-Man" comic book series, which was published in 1963, Spider-Man faced off against Vulture (Adrian Toomes), who used his original flying suit to carry out a series of robberies across the city. Spider-Man defeated Vulture after an intense battle in the air, and this marked the beginning of his long list of battles with some of the greatest super villains in the Marvel Universe.