The main female performer in an opera is known as a prima donna. The term "prima donna" is Italian for "first lady" and is used to refer to the leading female singer in an opera. The prima donna is usually the star of the show and is usually the most talented and experienced singer in the cast.
The main female performer in an opera is typically referred to as the soprano. The soprano is often the protagonist or leading lady of the story, and her role is typically associated with singing high and powerful notes.