The actor who has played in the most Edgar Allan Poe films is Vincent Price. Vincent Price was a renowned American actor known for his work in horror films, including several adaptations of Edgar Allan Poe's works. He portrayed characters in numerous Poe-inspired films, such as "House of Usher" (1960), "The Pit and the Pendulum" (1961), "Tales of Terror" (1962), "The Raven" (1963), and "The Masque of the Red Death" (1964), among others. Vincent Price's distinct voice and his portrayal of Poe's characters contributed to his association with the author's works in the realm of film.