System calls are a fundamental mechanism for applications to interact with an operating system (OS). They allow applications to request services from the OS, such as creating a new process, opening a file, or allocating memory. System calls provide a layer of abstraction between the application and the hardware, making it easier for programmers to write portable code that will work on different hardware platforms. Additionally, system calls provide a level of security by controlling access to system resources and ensuring that applications do not interfere with each other or the OS itself.