Lily Tomlin voiced Ms. Frizzle in the cartoon adaptation of the educational book series "The Magic School Bus." "The Magic School Bus" book series, written by Joanna Cole and illustrated by Bruce Degen, follows the adventures of a lively and eccentric science teacher named Ms. Valerie Frizzle and her class of students. The animated television series, also titled "The Magic School Bus," aired from 1994 to 1997 and featured Lily Tomlin as the voice of Ms. Frizzle. The show combined entertainment with educational content, taking the students on exciting field trips in their magical school bus, exploring scientific concepts and phenomena.