Alyssa Milano starred in the fantasy television drama "Charmed." The show, which aired from 1998 to 2006, followed the lives of three sisters, played by Milano, Shannen Doherty, and Holly Marie Combs, who discover that they are witches with magical powers. The show became a cult classic and was praised for its strong female characters, intricate mythology, and exploration of themes such as sisterhood, love, and destiny.