Cellular respiration is the process by which cells break down organic molecules, typically glucose, to release energy in the form of ATP (adenosine triphosphate). It is a vital metabolic process that occurs in the cells of all living organisms. Cellular respiration can be divided into three main stages: glycolysis, the citric acid cycle (also known as the Krebs cycle), and oxidative phosphorylation (including the electron transport chain).
Glycolysis:
Glycolysis occurs in the cytoplasm of the cell and does not require oxygen. It begins with the breakdown of one molecule of glucose (a six-carbon sugar) into two molecules of pyruvate (a three-carbon compound). This process involves a series of enzymatic reactions and yields a small amount of ATP and NADH (nicotinamide adenine dinucleotide) as energy carriers.
Citric Acid Cycle (Krebs Cycle):
The pyruvate molecules produced in glycolysis move into the mitochondria, where the citric acid cycle takes place. The pyruvate is first converted into a compound called acetyl-CoA, which enters the citric acid cycle. During the citric acid cycle, acetyl-CoA is further broken down, releasing carbon dioxide and producing ATP, NADH, and FADH2 (flavin adenine dinucleotide). These energy carriers will be used in the next stage.
Oxidative Phosphorylation (including the Electron Transport Chain):
The final stage of cellular respiration takes place in the inner mitochondrial membrane and involves oxidative phosphorylation and the electron transport chain. NADH and FADH2 generated in glycolysis and the citric acid cycle donate their electrons to the electron transport chain. As electrons pass through the electron transport chain, their energy is gradually released, which drives the pumping of protons (H+) across the inner mitochondrial membrane. This creates an electrochemical gradient.