The line "you talkin to me?" is from the 1976 film Taxi Driver, which stars Robert De Niro.
Taxi Driver is a psychological thriller directed by Martin Scorsese and written by Paul Schrader. It follows the story of Travis Bickle, a disturbed Vietnam War veteran who works as a taxi driver in New York City. The film was nominated for four Academy Awards, including Best Picture. It is considered one of the greatest films of all time.