The famous painting known for its enigmatic smile is the Mona Lisa, painted by Leonardo da Vinci in the 16th century. The painting depicts a woman, believed to be Lisa Gherardini, with a slightly smiling expression that has puzzled art enthusiasts for centuries. The painting's enigmatic smile, along with the use of sfumato (blurring of edges), has made it an iconic masterpiece that is celebrated as a cultural treasure till this day.