Antidiabetic medications are used to manage blood glucose levels in individuals with diabetes. The specific side effects can vary depending on the type of medication, but here are common side effects associated with various classes of antidiabetic drugs: **1. Metformin (Biguanides):** - Common side effects: Nausea, diarrhea, stomach upset, and loss of appetite. These side effects often subside with continued use. **2. Sulfonylureas (e.g., Glipizide, Glyburide):** - Common side effects: Low blood sugar (hypoglycemia), weight gain, and gastrointestinal disturbances. **3. Meglitinides (e.g., Repaglinide, Nateglinide):** - Common side effects: Hypoglycemia, weight gain, and mild gastrointestinal issues. **4. Thiazolidinediones (e.g., Pioglitazone, Rosiglitazone):** - Common side effects: Weight gain, fluid retention, and increased risk of bone fractures. Pioglitazone has also been associated with an increased risk of bladder cancer. **5. Alpha-glucosidase Inhibitors (e.g., Acarbose, Miglitol):** - Common side effects: Gastrointestinal problems such as flatulence, bloating, and diarrhea, particularly when consuming carbohydrates. **6. DPP-4 Inhibitors (e.g., Sitagliptin, Saxagliptin):** - Common side effects: Headache, upper respiratory tract infections, and joint pain. **7. GLP-1 Receptor Agonists (e.g., Exenatide, Liraglutide):** - Common side effects: Nausea, vomiting, diarrhea, and abdominal pain. These side effects may lessen over time. **8. SGLT2 Inhibitors (e.g., Canagliflozin, Dapagliflozin):** - Common side effects: Increased urination, genital yeast infections, urinary tract infections, and low blood pressure. These drugs may also increase the risk of ketoacidosis in rare cases. **9. Insulin:** - Common side effects: Hypoglycemia, weight gain, injection site reactions, and allergic reactions. It's important to note that not everyone will experience these side effects, and some individuals may tolerate certain medications better than others. The choice of antidiabetic medication is based on various factors, including the type of diabetes, individual health, and potential side effects. Patients should work closely with their healthcare providers to monitor their blood glucose levels, adjust medication dosages if needed, and manage any side effects that may arise. In some cases, lifestyle modifications and dietary changes can complement or reduce the need for antidiabetic medications. Always follow your healthcare provider's guidance and report any concerning side effects promptly.