The character who says "Don't make me run, I'm full of chocolate!" in "The Simpsons" is Homer Simpson. In the episode titled "King-Size Homer" from the seventh season, Homer decides to gain weight to reach the point where he can work from home using disability benefits. He wears a weight gain suit and attempts to avoid any physical activity. When his boss Mr. Burns suggests running, Homer responds with the iconic line, "Don't make me run, I'm full of chocolate!" It is a humorous moment that reflects Homer's love for food and his reluctance to engage in exercise.