Yes, there can be side effects associated with the use of hydroquinone. Hydroquinone is a skin-lightening agent that is commonly used to treat hyperpigmentation, such as dark spots, age spots, and melasma. However, it can cause skin irritation and other side effects, particularly with long-term use or use of high concentrations. Some of the possible side effects of hydroquinone may include: Skin irritation, including redness, itching, and burning Dryness, flakiness, or peeling of the skin Hypersensitivity to sunlight, leading to increased risk of sunburn and skin damage Skin discoloration or uneven skin tone Darkening of the skin in rare cases