Controlled experiments may sometimes be impossible due to ethical or practical reasons. For example, it may not be ethical to perform a controlled experiment on humans if the experiment involves potentially harmful treatments or interventions. In such cases, researchers may have to rely on observational or quasi-experimental methods instead. Additionally, some phenomena may be difficult to manipulate or control in a laboratory setting, making controlled experiments impractical or impossible. Lastly, budget and time constraints may also limit the feasibility of conducting controlled experiments.