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Why are controlled experiment sometimes impossible?

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Experiments that require testing on humans are influenced by genetic makeup, metabolism and psychology, among other factors, all of which are beyond human control.
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Controlled experiments are sometimes impossible because of practical, ethical, or logistical reasons. Practical reasons include a lack of resources or the complexity of the experiment. Ethical reasons include the inability to control or predict the outcome of the experiment, or the potential for harm to occur. Logistical reasons include the difficulty of controlling all variables in the experiment, or the inability to replicate the experiment in different settings.
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Practical reasons include a lack of resources or the complexity of the experiment. Ethical reasons include the inability to control or predict the outcome of the experiment, or the potential for harm to occur. 
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Controlled experiments may sometimes be impossible due to ethical or practical reasons. For example, it may not be ethical to perform a controlled experiment on humans if the experiment involves potentially harmful treatments or interventions. In such cases, researchers may have to rely on observational or quasi-experimental methods instead. Additionally, some phenomena may be difficult to manipulate or control in a laboratory setting, making controlled experiments impractical or impossible. Lastly, budget and time constraints may also limit the feasibility of conducting controlled experiments.
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