The 1622 attack on English settlers that resulted in the deaths of 347 people occurred in Jamestown, Virginia.
Jamestown was the first permanent English settlement in North America, established in 1607. In 1622, the Powhatan Confederacy, a group of Native American tribes that had initially traded with the English settlers, launched a surprise attack on the settlement, killing 347 people, including men, women, and children. The attack was led by Chief Opechancanough, who sought to drive the English settlers out of Powhatan lands. The attack had a significant impact on English attitudes towards Native Americans and led to increased violence and conflict between the two groups. The Jamestown settlement continued to grow and eventually became the capital of the Virginia Colony.