Unfortunately, there is no medicine to lower creatinine in blood. Dialysis is the only option when creatinine levels are high and have reached 8 or more. However, there are certain lifestyle changes that can help reduce creatinine levels. These include limiting protein intake, reducing salt and sugar intake, avoiding alcohol and smoking, and increasing physical activity. It is also important to stay well hydrated and get enough sleep. Additionally, certain medications can help reduce creatinine levels, but these should be discussed with and prescribed by a doctor.